logo ipa

Project Proposal

Title:Novel cancer therapies and targeted technologies for diagnosis, patients risk definition and disease monitoring.
Priority:1.Economic, Social and Institutional Cooperation
Measure:1.1 - Research and Innovation
Description:We aim at presenting a high-impact Trans-Adriatic collaborative project on the development of research on innovative anti-cancer therapies, and of the related technologies for diagnosis, patients risk definition and disease monitoring. Our research allowed us to identify the molecule Trop-2 as a key controller of cancer growth and metastatization in man. Therefore, it is now essential to define its mechanisms of action, to clarify its structure, to develop targeted drugs / study their efficacy and to define who will benefit the most from these therapies. Hence, we plan to develop a collaborative project that will allow to benefit from the expertise of the partecipants and to transfer knowledge in key areas of leading-edge cancer research, both for basic science and at a clinical level.
Partners already involved:Jozef Stefan Institute, Ljubljana. Sinchrotron of Trieste, Italy. Oncoxx Biotech, Pescara, Italy.
Partners searched:o Basic Science Laboratories with expertise in the areas covered by the project. o Established or starting-up Biotech Companies with interest in the field of cancer.

Contact details

Project promoterUnit of Cancer Pathology, CESI center for Excellence, Foundation University of Chieti
Typology:Academic and Biotech Institution
Description of main activities:1. Definition of the mechanisms of action of Trop-2 a.Signaling 2.Definition of the Trop-2 structure a.X-ray crystallography 3.Development of targeted drugs a.monoclonal antibodies b.Trop-2-dependent kinases inhibitors 4.Definition of the effects of anti-Trop-2 drugs a.pre-clinical models b.clinical trials in man 5.Definition of the patient sub-groups who will benefit from anti-Trop-2 therapies a.prognostic studies b.molecular taxonomy c.therapy monitoring
Contact person:Prof. Saverio Alberti
Phone number:+39-0871-541551
Email:s.alberti @ unich.it
Is the project promoter the projectís potential Lead Partner? Yes
If not, is the potential Lead Partner already being chosen?  


Dear users, we inform you that, due to an improvement to the network infrastructure, in order to have access to the M.I.S. we will have to replace the link  https://sso.adriaticipacbc.org/gestionale  with   https://sso.adriaticipacbc.eu/gestionale